Adrenaline (epinephrine)

Adrenaline (epinephrine) is a catecholamine hormone produced by the body and used therapeutically to reduce swelling due to allergies. I tis msot often measured using HPLC.

adrenaline (epinephrine): CAS No. 51-43-4, C9H13NO3, molecular weight 183.20, melting point 211-212°C, vapor pressure 0.00mm Hg at 25°C, slightly water soluble is a white crystalline solid. It is a catecholamine hormone and an alpha-adrenergic agonist produced by the body that in synthetic form is a drug of choice to reverse the effects of serious acute, hypersensitivity reactions (e.g, from food, bee sting, or drug allergy). A subcutaneous injection of adrenaline (epinephrine) rapidly relieves itching, hives, and swelling of lips, eyelids, and the tongue. The main effects of therapeutic parenteral doses of it are relaxation of smooth muscle of the bronchial tree, cardiac stimulation and dilation of skeletal muscle vasculature. It is also sometimes successful in restarting the heartbeat following cardiac arrest. It increases diastolic blood pressure and improves coronary blood flow. Its most common uses are to relieve respiratory distress due to bronchospasm and to prolong the action of local anesthetics. It is also sometimes used therapeutically to control superficial bleeding and to reduce uterine contractions during labor. It is most frequently measured in blood plasma, urine and tissue in clinical studies and evaluations. It is most often measured using reversed phase HPLC.

Combinatorial Sample Analysis by HPLC/ELSD

Examples of the use of reversed phase HPLC with ELSD detection are given for combinatorial drug analysis. Separations of an aspartate antagonist in synthesis solution and mixture of catecholamines are shown.