Topics - Vancomycin

Vancomycin Vancomycin is a macrolytic glycopepetide having a molecular weight of 1449.22 and containing 54.69% carbon, 5.22% hydrogen, 4.89% chlorine, 8.70% nitrogen and 26.50% oxygen. It is an amphoteric glycopeptide and an antibiotic substance produced by Streptomyces orientalis contained in Indian and Indonesian soil. Vancomycin has been used as a very effective chiral stationary phase as it has 18 chiral centers and three shallow molecular cavities so some inclusion can take place. There are many dipoles on the molecule covering a wide range of polar intensities, a number of polarizable groups that can provide induced dipole ineteractivity and a range of dispersive groups that can provide dispersive (hydrophobic) interactivity. Vancomycin can be bonded to silica to provide a stable chiral bonded phase. In chromatography, vancomycin can be used in both the polar and dispersive mode by employing the appropriate complementary mobile phases. The macrolytic glycopeptides are used extensively as stationary phases in chiral chromatography