Topics - Teicoplanin

Teicoplanin Teicoplanin (teichomycin) is an antibiotic glycopeptide and is related to vancomycin but is produced by Actinoplanes teichmyceticus. Its antibiotic action involves the inhibition of peptidoglycan synthesis in the cell wall of gram-positive bacteria. The molecule is comprised of 5 major components joined by specific fatty acid moieties. Teicoplanin has 20 chiral centers and 4 fused rings and, like vancomycin has a complex structure that provides a wide range of polar, dispersive and potential ionic interactive sites. Like vancomycin, in chromatography, teicoplanin is a very effective chiral stationary phase. Tycoplanin can be bonded to silica to provide a stable, very selective, chiral bonded phase. It can be used very effectively in either the polar or reversed phase mode by the judicious selection of the appropriate mobile phase. The macrolytic glycopeptides are used extensively as stationary phases in chiral chromatography