Topics - Metoprolol

Metoprolol Metoprolol or Toprol XL is a beta-selective (cardioselective) adrenoceptor or blocking agent lacking intrinsic sympathomimetic activity. It is employed as a antihypertensive and antianginal agent and used in the treatment of myocardial infarction.. Its chemical name is 1-[4-(2-Methoxyethyl)phenoxyl]-3-[(1-metylethyl)amino]-2-propanol, it has a molecular weight of 267.38 and elemental analysis shows it contains 63.56% carbon, 6.00% hydrogen, 9.27% nitrogen and 21.17% oxygen. It is often prescribed as the succinate which is a white powder, molecular weight 652.8. Metapropol reacts directly with the fluorescence agent 4(N-chloroformethyl-N-methylamino-7-N-N-dimethylamino sulphonyl-2,1,2-benzoxydazole to form a fluorescent derivative as a 1-1 aduct with the secondary amino group of the B blocker. The reaction proceeds readily with no catalyst. The derivatives can be separated on a reversed phase column 15 cm long and 4.6 mm in diameter packed with 5 micron particles using an appropriate aqueous/solvent mixture as the mobile phase