Topics - Low Dispersion

Low Dispersion Dispersion, in this chromatography context, refers to the capacity of a column or some part of the mobile phase conduit system to cause ‘peak dispersion’ or peak spreading. Lowdispersion indicates the contribution to peak spreading is small. It is a term usually given to describe parts of the mobile phase system other than the column. For example low dispersion unions are designed to ensure that dispersion that occurs as a solute band passes through them is strictly constrained. Low dispersion tubing is made to limit dispersion that can take place in connecting tubes between column and detector (an example of which is Serpentine tubing). There are also low dispersion sample valves and low dispersion detector sensor cells all of which are carefully designed to limit any peak spreading that may take place in them. It is extremely important to carefully restrict any peak dispersion that takes place outside the column as such dispersion can impair (and in some cases destroy) the separation that is achieved in the column.