Topics - Acetaminophen

Acetaminophen Acetaminophen is an analgesic and an antipyretic, but the exact mechanism of the drug action is not fully understood. It appears to relieve pain by raising the pain threshold so that a greater amount of pain is necessary before it can be felt. Its antipyretic action results from its effect on the heat-regulating centers of the brain. Chemically, acetaminophen is p-hydroxy acetanilide, it has a molecular weight of 151.16 and elemental analysis shows it contains 67.38% carbon, 9.43% hydrogen, 5.24% nitrogen and 17.95% oxygen. Acetaminophen is prescribed for arthritis but is not an anti-inflammatory, it is mainly used to help reduce temperature and as a mild analgesic. Acetaminophen tablets have been successfully analyzed using reversed phase (C18) columns 20-25 cm long 3-4.6 mm in diameter using a strongly polar, water-methanol-acetonitrile mixture with a tetramethylammonium hydroxide buffer as the mobile phase. By employing a C18 stationary phase strong dispersive interactions are exploited in the stationary phase whereas predominantly polar interactions are active in the mobile phase. Separations can be easily obtained in 5 to 10 minutes