Preparative Chromatography - Packing Preparative Columns > Radial Compression > Page 36

Radial Compression

In the radial compression column, shown in figure 17, the column walls are flexible, which is achieved by packing the bed into a tubular polymer cartridge (terminated by an appropriate stainless steel frit). The cartridge is contained inside a supporting stainless steel cylindrical column. The column is filled with a very dense slurry of the packing material and another frit fitted to the top of the bed. The bed is then compressed radially by applying pressure to the outside walls of the polymer cartridge. The applied pressure may be either pneumatic or hydraulic.


Figure 17 Radial Compression for Preparative Column Bed Stabilization