Liquid Chromatography - Macroporous Polymers 2

Most cross-linked polystyrene resins employed in LC are the macro-reticular type and can be produced with almost any desired pore size, ranging from 20Å to 5,000Å. Underivatized, they exhibit strong dispersive type interactions with solvents and solutes together with some induced polarizability arising from the aromatic nuclei in the polymer if strongly polar solutes are being separated. Consequently, the untreated resin has found some use as an alternative to the C8 and C18 reverse phase columns based on silica.

Courtesy of TOSOHAAS Inc.

Figure 39. The Separation of a Crude Protein Extract by Exclusion on a Micro-Reticulated Resin Column