Preparative Chromatography - The Preparative Separation of the Enantiomers of Chlorokynurenine > Page 71

The first fraction of the second separation is bulked with the original mixture and recycled. An analytical separation of fraction 2 of the second separation is shown in figure 40. The separation was carried out under the same conditions as those shown in the separation in figure 38. It is seen that the second enantiomer is also obtained in a state of high purity and furthermore because the third fraction is recycled there is little loss of material

 

Courtesy of ASTEC Inc.

 

Figure 40. The Second Preparative Separation of the Isomers of Nicardipine